Mac and Cheese Meatloaf Casserole
Mac and Cheese Meatloaf Casserole is a deliciously comforting dish that brings together two beloved meals into one hearty casserole. This recipe features a flavorful ground beef meatloaf base topped with creamy macaroni and cheese, making it perfect for family dinners and casual gatherings. With its rich flavors and satisfying textures, this casserole is sure to please everyone at the table.
Why You’ll Love This Recipe
- Quick to Prepare: With just 18 minutes of prep time, you can have this hearty dish ready for the oven in no time.
- Family-Friendly: Kids and adults alike will love the combination of meatloaf and macaroni and cheese.
- Versatile Ingredients: You can easily substitute ingredients based on what you have on hand or personal preferences.
- Leftover Friendly: This casserole makes excellent leftovers, perfect for lunches or quick dinners throughout the week.
- Crowd-Pleaser: Ideal for potlucks or gatherings, it’s a dish that everyone will want to try.
Tools and Preparation
Before diving into this delightful recipe, gather your tools to ensure a smooth cooking experience.
Essential Tools and Equipment
- Mixing bowls
- Ziploc bags
- Rolling pin
- Whisk
- Baking dish (9 x 13 inch)
- Measuring cups and spoons
Importance of Each Tool
- Mixing bowls: Essential for combining ingredients thoroughly without making a mess.
- Ziploc bags: Great for crushing crackers easily without worrying about spills.
- Whisk: Perfect for mixing liquids evenly, ensuring a smooth texture in your macaroni mixture.

Ingredients
To create this delicious Mac and Cheese Meatloaf Casserole, gather the following ingredients:
For the Meatloaf Base
- 1 cup ketchup
- 1 cup Sweet Baby Ray’s Hickory & Brown Sugar barbecue sauce
- 2 lbs lean ground beef
- 30 Ritz Crackers
- 2 oz Lipton onion soup mix
- 2 eggs
For the Macaroni Topping
- 3 cups macaroni noodles
- 2 cups milk
- 10.5 oz condensed cheddar cheese soup
- 1 teaspoon salt
- 1 teaspoon pepper
- 1 tablespoon garlic powder
- 1 tablespoon onion powder
- 4 cups shredded mozzarella and cheddar cheese blend
How to Make Mac and Cheese Meatloaf Casserole
Step 1: Preheat the Oven
Preheat your oven to 350°F (175°C) to ensure it’s hot enough for baking.
Step 2: Prepare the Sauce Mixture
- In a medium mixing bowl, combine the ketchup and barbecue sauce.
- Stir until well mixed. Set aside for later use.
Step 3: Assemble the Meatloaf Mixture
- Place the ground beef in a large mixing bowl.
- Crush the Ritz crackers in a Ziploc bag using a rolling pin until fine crumbs form.
- Add the crushed crackers to the bowl with ground beef.
- Mix in the onion soup mix and eggs.
- Pour in ½ cup of the reserved ketchup/barbecue sauce mixture.
- Use your hands to combine all ingredients thoroughly.
Step 4: Form and Bake the Meatloaf
- Transfer the meatloaf mixture into a greased 9 x 13 inch baking dish.
- Press it down evenly across the dish surface.
- Spread the remaining ketchup/barbecue sauce on top of the meatloaf.
- Bake in preheated oven for 30 minutes.
Step 5: Cook Macaroni
While the meatloaf is baking:
1. Cook macaroni noodles according to package instructions until al dente, then drain.
Step 6: Prepare Cheesy Sauce
- In another large mixing bowl, combine milk and condensed cheddar cheese soup.
- Whisk until smooth with no lumps remaining.
- Add salt, pepper, garlic powder, and onion powder; whisk again until blended.
- Stir in cooked macaroni noodles until well coated with sauce.
- Mix in 2 cups of shredded cheese until evenly distributed.
Step 7: Assemble Casserole
- After baking meatloaf for 30 minutes, remove it from oven.
- Pour macaroni mixture over meatloaf evenly across surface.
- Top with remaining 2 cups of shredded cheese.
Step 8: Final Bake
Return casserole to oven:
1. Bake until cheese is melted and slightly browned, about 17-20 minutes.
Step 9: Serve
Once baked, remove from oven:
1. Let sit for a few minutes before slicing into portions.
2. Serve hot and enjoy this delightful Mac and Cheese Meatloaf Casserole!
How to Serve Mac and Cheese Meatloaf Casserole
Serving Mac and Cheese Meatloaf Casserole can be a delightful experience. This hearty dish is perfect for family gatherings or weeknight dinners. Here are some suggestions to enhance your serving experience.
Complement with Fresh Salad
- Garden Salad: A light garden salad with mixed greens, tomatoes, and cucumbers adds freshness.
- Caesar Salad: Tossed romaine with creamy dressing and croutons pairs well with the richness of the casserole.
Pair with Bread Options
- Garlic Bread: Crispy garlic bread is an excellent choice for soaking up any extra cheese sauce.
- Dinner Rolls: Soft dinner rolls can complement the meal and provide a comforting touch.
Add Some Colorful Vegetables
- Roasted Vegetables: Seasonal roasted vegetables like carrots, zucchini, and bell peppers can brighten up the plate.
- Steamed Broccoli: Lightly steamed broccoli adds nutrition and a pop of color alongside the casserole.
How to Perfect Mac and Cheese Meatloaf Casserole
To achieve the best results when making Mac and Cheese Meatloaf Casserole, consider these helpful tips.
- Use High-Quality Ingredients: Select fresh ground beef and quality cheeses for richer flavors.
- Don’t Overmix the Meatloaf: Mix just until combined to keep it tender; overmixing can make it tough.
- Customize Seasonings: Feel free to adjust salt and spices based on your taste preferences for a more personalized flavor.
- Let It Rest Before Serving: Allowing the casserole to sit for a few minutes after baking helps it set for easier slicing.
Best Side Dishes for Mac and Cheese Meatloaf Casserole
Pairing side dishes with Mac and Cheese Meatloaf Casserole enhances your meal. Here are some great options that complement this comforting dish.
- Coleslaw: A tangy slaw adds crunch and balances the richness of the casserole.
- Baked Beans: Sweet baked beans provide a hearty companion that’s full of flavor.
- Corn on the Cob: Grilled or boiled corn on the cob brings a sweet touch that pairs perfectly.
- Mashed Potatoes: Creamy mashed potatoes make this meal even more filling and delicious.
- Fruit Salad: A refreshing fruit salad offers a sweet contrast to savory flavors in the casserole.
- Crispy Potato Wedges: Baked potato wedges add a satisfying crunch alongside this cheesy dish.
Common Mistakes to Avoid
To ensure your Mac and Cheese Meatloaf Casserole turns out perfectly, be mindful of these common mistakes.
- Bold ingredient measurements: Always measure your ingredients accurately. Using too much or too little can affect the texture and flavor of your casserole.
- Bold neglecting to preheat: Forgetting to preheat the oven can lead to uneven cooking. Make sure your oven is set to 350F before placing your dish inside.
- Bold overmixing the meatloaf: Mixing the beef too much can result in a dense meatloaf. Combine the ingredients just until fully mixed for a tender result.
- Bold skipping the resting time: Cutting into the casserole immediately after baking can cause it to fall apart. Let it sit for a few minutes before slicing.
- Bold not using enough cheese: Cheese is essential for flavor and creaminess in this dish. Be generous when adding cheese both in the macaroni and on top.

Storage & Reheating Instructions
Refrigerator Storage
- Store leftovers in an airtight container.
- Keep in the refrigerator for up to 3 days.
Freezing Mac and Cheese Meatloaf Casserole
- Allow the casserole to cool completely before freezing.
- Wrap tightly in plastic wrap or use a freezer-safe container.
- It can be frozen for up to 3 months.
Reheating Mac and Cheese Meatloaf Casserole
- Oven: Preheat to 350F, cover with foil, and bake for about 20-30 minutes until heated through.
- Microwave: Place individual portions on a microwave-safe plate and heat in short intervals, stirring in between, until warm.
- Stovetop: Heat on low in a skillet, stirring occasionally until warmed through.
Frequently Asked Questions
Here are some common questions about making Mac and Cheese Meatloaf Casserole.
What is Mac and Cheese Meatloaf Casserole?
Mac and Cheese Meatloaf Casserole is a comforting dish that layers a savory ground beef meatloaf with creamy macaroni and cheese baked together.
Can I use ground turkey instead of beef?
Yes! Ground turkey is a great alternative that will still yield delicious results while being lower in fat.
How long does it take to cook Mac and Cheese Meatloaf Casserole?
The total time for preparation and cooking is approximately 1 hour and 8 minutes, making it a great option for dinner.
Can I make this dish ahead of time?
Absolutely! You can prepare it ahead of time, refrigerate it unbaked, then simply pop it into the oven when you’re ready to serve.
Final Thoughts
Mac and Cheese Meatloaf Casserole is not just filling but also incredibly versatile. Feel free to customize it by adding vegetables or swapping cheeses based on your taste preferences. This hearty dish is sure to please everyone at your table!
Mac and Cheese Meatloaf Casserole
- Total Time: 1 hour 18 minutes
- Yield: Approximately 8 servings 1x
Description
Mac and Cheese Meatloaf Casserole is a delightful fusion of two beloved comfort foods that promises to satisfy your family and friends. This hearty dish features a savory ground beef meatloaf base, topped with creamy macaroni and cheese, creating a deliciously layered experience. Perfect for weeknight dinners or casual gatherings, this casserole is not only quick to prepare but also incredibly versatile.
Ingredients
- 2 lbs lean ground beef
- 1 cup ketchup
- 1 cup barbecue sauce
- 30 Ritz Crackers
- 3 cups macaroni noodles
- 2 cups milk
- 10.5 oz condensed cheddar cheese soup
- 4 cups shredded mozzarella and cheddar cheese blend
- Salt
- Pepper
- Garlic powder
- Onion powder
Instructions
- Preheat the oven to 350°F (175°C).
- In a mixing bowl, combine ketchup and barbecue sauce; set aside.
- In another large bowl, mix ground beef, crushed Ritz crackers, onion soup mix, eggs, and half of the reserved sauce.
- Spread the meatloaf mixture in a greased 9 x 13 inch baking dish; top with remaining sauce.
- Bake for 30 minutes.
- Cook macaroni according to package instructions; drain.
- In a separate bowl, whisk together milk and cheddar cheese soup until smooth; add seasonings and cooked macaroni.
- Pour the macaroni mixture over the meatloaf; top with remaining cheese.
- Bake until cheese is melted and slightly browned (about 17-20 minutes).
- Let cool before slicing; serve warm.
- Prep Time: 18 minutes
- Cook Time: 60 minutes
- Category: Main
- Method: Baking
- Cuisine: American
Nutrition
- Serving Size: 1 slice (approximately 200g)
- Calories: 450
- Sugar: 10g
- Sodium: 800mg
- Fat: 20g
- Saturated Fat: 10g
- Unsaturated Fat: 8g
- Trans Fat: 0g
- Carbohydrates: 45g
- Fiber: 3g
- Protein: 25g
- Cholesterol: 80mg
Keywords: For added flavor, consider mixing in sautéed vegetables like bell peppers or spinach into the macaroni topping. Ground turkey can be substituted for lean ground beef for a lighter option. Leftovers can be stored in an airtight container for up to three days or frozen for later enjoyment.
